We are a dedicated team of researchers led by Professor Dr Holly Shiels. We are passionate about advancing scientific knowledge and making a positive impact in the field of physiology, pollution and climate change, and micro-nano plastic research. 

Our research delves into the molecular and cellular mechanisms that influence cardiac function in response to environmental changes, exploring how these changes impact organismal metabolism, locomotion, and behavior to understand the intersection between the cardiovascular system and the environment in affecting overall fitness. We study the interaction between temperature and hypoxia on cardiac health across various species, aiming to identify conserved and fundamental biological pathways. Additionally, a group of our lab members focuses on micro and nano plastic research, addressing a range of issues from marine microplastic pollution to vehicle-related microplastics, such as tyre wear. Our recent work has concentrated on the impact of air and water pollution on cardiac health, utilizing whole animal models (mice), tissue models (fish, sheep, mouse), and human-induced pluripotent stem cells (hiPSCs). With a strong commitment to excellence, innovation, and collaboration, we strive to push the boundaries of scientific discovery. Our lab is equipped with state-of-the-art facilities and cutting-edge technologies to support our research endeavours. We are proud to contribute to the scientific community and train the next generation of scientists.